Changes

* No '''Day 1-7:''' a wash-out period of at least one week is needednecessary. * Start '''Day 8:''' start venlafaxine the next day in a normal dosage of 37,5 mg or 75 mg(slow release) /day. Increase the dose with about 25% of the target dose every 3 days

* Bupropion By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites have long elimination times) it is assured that all bupropion has left the body and no drug interactions occur. * Bupropion slows the metabolism of venlafaxine by CYP2D6.<ref> Kennedy et al, [http://www.ncbi.nlm.nih.gov/pubmed/11926715?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, so plasma concentrations will reduce graduallyand sexual dysfunction effects.]. J Clin Psychiatry 2002 March;63(3):181-6.</ref> }}