| to = vortioxetine
| stop =
* '''Before day 8:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. * '''Day 8:''' When a dosage of 150 mg/day is reached, stop administration.{{StopBupropion}}
| start =
{{washout8-14}}* ''' Day 1: ''' Start vortioxetine with a dosage of 5 mg/day.* '''Day 148:''' start administration increase dosage of vortioxetine in to a normal dosage of 10 mg/day.
| info =
* Bupropion and its metabolites have long elimination times (t1/2: 20-37 hours), so plasma concentrations will reduce gradually.slows the metabolism of vortioxetine via CYP2D6
}}
