Changes

{{washout8-14}}* ''' Day 1: ''' Start vortioxetine with a dosage of 5 mg/day.* '''Day 158:''' start administration increase dosage of vortioxetine in to a normal dosage of 10 mg/day.

* Bupropion and its metabolites have long elimination times (t1/2: 20-37 hours), so plasma concentrations will reduce gradually. Bupropion is an inhibitor slows the metabolism of vortioxetine via CYP2D6.* Vortioxetine is recently marketed, so in future more data wille become available (test for VJC 2015)