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| from = citalopram
| to = vortioxetine
| stop = * '''Before day 1:''' Gradually reduce dosage of citalopram to a maximum of 20 mg/day, when this dosage is > 20 mg/day. * '''Day 1:''' When a dosage of 20 mg/day is reached{{StopSSRI, stop administration. SNRI}}| start = * A wash-out period is not necessary, but care is needed.* '''Day 1:''' Start administration of vortioxetine in a dosage of 10 mg/day.{{StartAntidepressant}}
| info =
* Citalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxeine. * Patients could be directly switched from a SSRI or a SNRI to Safe target dose vortioxetine = 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref> * {{theorSS}}
}}
