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Clomipramine-bupropion

288 bytes removed, 12:12, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.* '''Day 1-3:''' reduce dosage of clomipramine to 50 mg/day.* '''Day 4-7:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 8:''' stop administration of clomipramine. {{stopClomipramine}}
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* '''Day 1:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of clomipramine according to the scheme above.
* Bupropion is an inhibitor of CYP2D6, which metabolizes clomipramine.
* {{RiskSeizureBupropionTCA}}
{{review}}
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