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Clomipramine-citalopram

456 bytes removed, 12:01, 30 June 2023
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* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 3:''' reduce dosage of clomipramine to 10 mg/day.* '''Day 8:''' stop administration of clomipramine.{{TCAdecrease25p3d}}| start = * '''Day 1:''' simultaneously start administration of citalopram in a normal dosage of 20 mg/day.{{StartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Citalopram is a very weak inhibitor of CYP2D6, which metabolizes clomipramine.{{review}}Safe target dose citalopram = 20 mg }}

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