| to = duloxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.* '''Day 1-7:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 8:''' stop administration of clomipramine. {{TCAdecrease25p3d}}| start = {{StartAntidepressant}}* '''Day 8-14:''' a wash-out period of one week is necessary.| info =* '''Day 15:''' start administration of Safe target dose duloxetine in a normal dosage of = 60 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Duloxetine is an inhibitor of CYP2D6, which metabolizes clomipramine.
}}
