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Clomipramine-escitalopram

324 bytes removed, 12:58, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 3:''' reduce dosage of clomipramine to 10 mg/day.* '''Day 8:''' stop administration of clomipramine. {{stopClomipramine}}
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* '''Day 1:''' simultaneously start administration of escitalopram in a normal dosage of 10 mg/day.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Escitalopram is a very weak inhibitor of CYP2D6, which metabolizes clomipramine.
{{review}} }}
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