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Clomipramine-fluoxetine

1 byte removed, 15:33, 11 September 2009
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* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.
* '''Day 78:''' stop dosage of clomipramine.
| start =
* '''Day 108:''' start administration of fluoxetine in a normal dosage of 20 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) and CYP3A4 (moderate), which metabolize clomipramine.
}}
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