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Combining-Carbamazepine-Gabapentin

471 bytes removed, 15:50, 23 April 2010
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{{Drugcombi
| base = carbamazepine
| add = gabapentinegabapentin| info = * Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases. * Gabapentine is eliminated unchanged by the kidney for 100%.* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998&nbsp;155:12-21}}</ref>
| start =
* Start gabapentine gabapentin according to the general dosing advice.{{CombiCaGa}}
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">{{Drugscominteract|carbamazepine-with-gabapentinegabapentin-1147-0-497-0|carbamazepine|gabapentinegabapentin}}</ref>
}}
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