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* Carbamazepine The available data suggest that the combination of lithium and carbamazepine is principally metabolized by CYP3A4 (also CYP2C8)safe and effective, but is also a potent inducer especially for rapid-cycling patients.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of CYP1A2, CYP3A4 Safety and UDPEfficacy. Am J Psychiatry 1998;155:12-glucuronosyltransferases.21}}</ref>* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effectsand carbamazepine may work synergistically.<ref name="freeman"/>* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effectsPatients receiving both lithium and carbamazepine experience better prophylaxis against bipolar episodes than patients treated with either medication alone.<ref name="freeman"/>
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* The combination may rarely cause neurotoxicity ''without increased plasma levels''. <ref> {{Pubmed|8740344|Marcoux AW. Carbamazepine-lithium drug interaction. Ann Pharmacother 1996;30:547}}</ref>
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