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* Carbamazepine The available data suggest that the combination of lithium and carbamazepine is principally metabolized by CYP3A4 (also CYP2C8)safe and effective, but is also a potent inducer especially for rapid-cycling patients.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of CYP1A2, CYP3A4 Safety and UDPEfficacy. Am J Psychiatry 1998;155:12-glucuronosyltransferases.21}}</ref>* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effectsand carbamazepine may work synergistically.<ref name="freeman"/>* {{CombiBasic}}Patients receiving both lithium and carbamazepine experience better prophylaxis against bipolar episodes than patients treated with either medication alone.<ref name="freeman"/>
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* The combination may rarely cause neurotoxicity ''without increased plasma levels''. <ref> {{Pubmed|8740344|Marcoux AW. Carbamazepine-lithium drug interaction. Ann Pharmacother 1996;30:547}}</ref>
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{{CombiCaLi}}
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