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Combining-Carbamazepine-Lithium

183 bytes added, 09:49, 23 April 2010
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* The available data suggest that the combination of lithium and carbamazepine is safe and effective, especially for rapid-cycling patients.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>* Lithium and carbamazepine may work synergistically.<ref name="freeman"/>* Patients receiving both lithium and carbamazepine experience better prophylaxis against bipolar episodes than patients treated with either medication alone.<ref name="freeman"/>
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* The combination may rarely cause neurotoxicity ''without increased plasma levels''. <ref> {{Pubmed|8740344|Marcoux AW. Carbamazepine-lithium drug interaction. Ann Pharmacother 1996;30:547CombiCaLi}}</ref>* The combination of these two drugs in generally safe and effective, but it should be avoided for patients with comorbid CNS(central nervous system) disease.<ref''freeman''/ref>
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