editor, reviewer
154
edits
Changes
no edit summary
{{Drugcombi
| base = Carbamazepinecarbamazepine| add = Quetiapinequetiapine| info = * Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
| start =
* Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|15385830|Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91}}</ref>
* Add quetiapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref> <ref name=”bazire”> Bazire S, Pshychotropic Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref> <ref name="drugscomint">{{Drugscominteract|carbamazepine-with-quetiapine-497-0-1979-0|carbamazepine|quetiapine}}</ref>
| cave =
}}
