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| base = gabapentin
| add = lithium
| info = * Gabapentine is eliminated unchanged by the kidney for 100%.* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects. * This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. <ref name=”freeman”> {{PubmedGabapentinAdvantage|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21lithium}}</ref>
| start =
* Start lithium according to the general dosing advice.
| cave =
* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscom">
{{Drugscominteract|lithium-with-gabapentin-1147-0-1477-0|lithium|gabapentin}}</ref>
}}
