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| add = valproic acid
| info =
* Gabapentine is eliminated unchanged by the kidney for 100%. Changes in the rate of excretion can cause unwanted effects.* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases. * This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects.{{CombiNoInteraction}}
| start =
* Start valproic acid according to the general dosing advice.
| cave =
}}
