Changes

| info =  * Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.* {{CombiBasic}}| stop =

* Start carbamazepine with a daily dose of 200 mg and increase dose based on serum concentration if necessary. Check lamotrigines lamotrigine effect after 2 weeks of therapy and adapt dose if necessary. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref>| cave = * Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <refname="drugscomint"> {{PubmedDrugscominteract|12648898lamotrigine-with-carbamazepine-1430-0-497-0|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by |carbamazepine. J Clin Psychiatry 2005;66:400-1}}</ref>| cave = {{CombiCaLa}}