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| add = carbamazepine
| info =
* Lithium is eliminated by the kidney for about 95%The addition of carbamazepine allowes patients to function better while maintaining lower lithium levels.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Changes in the rate Mood stabilizer Combinations: A Review of excretion can cause unwanted effectsSafety and Efficacy.Am J Psychiatry 1998;155:12-21}}</ref>* Carbamazepine The available data suggest that the combination of lithium and carbamazepine is principally metabolized by CYP3A4 (also CYP2C8)safe and effective, but is also a potent inducer especially for rapid-cycling patients.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of CYP1A2, CYP3A4 Safety and UDPEfficacy. Am J Psychiatry 1998;155:12-glucuronosyltransferases.21}}</ref>* This combination of drugs Lithium and carbamazepine may have possible synergistic effectswork synergistically. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination<ref name="freeman"/>* Patients receiving both lithium and carbamazepine experience better prophylaxis against bipolar episodes than patients treated with either medication alone.<ref name="freeman"/>
| start =
* Start carbamazepine according to the general dosing advice.
| cave = * The combination may rarely cause neurotoxicity ''without increased plasma levels''.{{CombiCaLi}}
}}
