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Combining-Lithium-Valproic acid

114 bytes removed, 16:46, 21 April 2010
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| add = valproic acid
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* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
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