Changes

* Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites. * Gabapentine is eliminated unchanged by the kidney for 100%.* This combination of drugs may have possible synergistic effects. There are no reports for pharmacokinetic drug interactions. However, the combination will have additional side effects. <ref name=”freeman”> {{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>

* Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects. <ref name="drugscomdrugscomint">{{Drugscominteract|quetiapine-with-gabapentin-1147-0-1979-1274|quetiapine|gabapentin}}</ref>