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| base = quetiapine
| add = topiramate
| info = * Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites. * Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according general dosing advice.
| cave =
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscomdrugscomint">{{Drugscominteract|quetiapine-with-topiramate-1979-1274-2216-1469|quetiapine|topiramate}}</ref>
}}
