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* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
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* A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. <ref> {{Pubmed|15800164|Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2}}</ref>
* Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. <ref name="drugscom">
{{Drugscominteract|risperidone-with-lamotrigine-17441430-0848-22862019-01305|risperidone|lamotrigine}}</ref>
}}
