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| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start topiramate according general dosing advice.
| cave =
* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscom">{{Drugscominteract|risperidone-with-topiramate-2019-0-2216-0|risperidone|topiramate}}</ref>
}}
