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Combining-Risperidone-Topiramate

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* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
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