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* Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. <ref name="drugscom">{{Drugscominteract|aripiprazole-with-topiramate-233-0-2216-0|aripiprazole|topiramate}}</ref>
* Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather.
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