387
edits
Changes
Created page with '{{Drugcombi | base = Topiramate | add = Lamotrigine | info = * Topiramate induces CYP3A4 and is an inhibiter of CYP2C19. * Lamoptrigine is principally metabolised by UDP-glucuro...'
{{Drugcombi
| base = Topiramate
| add = Lamotrigine
| info =
* Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Topiramate does not cause a significant change in lamotrigine levels. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> Start topiramate according to the general dosing advice.
| cave =
}}
| base = Topiramate
| add = Lamotrigine
| info =
* Topiramate induces CYP3A4 and is an inhibiter of CYP2C19.
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Topiramate does not cause a significant change in lamotrigine levels. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> Start topiramate according to the general dosing advice.
| cave =
}}
