Revision as of 14:11, 15 June 2010 by Musys (nbsp: non-breakable-space as workaround no longer necessary)
Adding valproic acid to ziprasidone.
- Ziprasidone is metabolized by CYP1A2 (minor) and CYP3A4.
- Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
- Start valproic acid according to the general dosing advice.
- Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.
- Antipsychotics lower the seizure threshold and may antagonise the anticonvulsant effect of valproate. 
- Farmacotherapeutisch Kompas; Toxicologie (dutch)
- Farmacotherapeutisch Kompas - valproinezuur (dutch)
- KNMP; Informatorium Medicamentorum 2015; Monografie "valproaat" (Dutch)
- Interactions between aripiprazole and valproic acid on drugs.com
- Bazire S, Psychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.