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Dosulepine-sertraline

315 bytes removed, 14:12, 2 November 2015
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* '''Before day 1:''' gradually reduce dosage of dosulepine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of dosulepine to 50 mg/day.* '''Day 3:''' reduce dosage of dosulepine to 25 mg/day.* '''Day 7:''' stop administration of dosulepine.{{stopDosulepine}}
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* '''Day 89:''' start administration of sertraline in a normal dosage of 50 mg/day.* '''Day 2223:''' if necessary increase dosage of sertraline to 100 mg/day.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Sertraline is a weak inhibitor of CYP2D6, which metabolizes dosulepine.
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