* '''Before day 1:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.* '''Day 1:''' reduce dosage of doxepin to 50 mg/day.* '''Day 3:''' reduce dosage of doxepin to 25 mg/day.* '''Day 8:''' stop administration of doxepin.{{TCAdecrease25p3d}}| start = {{StartAntidepressant}}* A wash-out period is not necessary.| info =* Start administration of Safe target dose vortioxetine the next day in a dosage of = 10 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
