Escitalopram-fluoxetine
From Psychiatrienet
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Switch medication from escitalopram to fluoxetine.[1] [2]
Stop escitalopram - Before day 1: gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is >10 mg/day.
- Day 1: reduce dosage of escitalopram to a maximum of 5 mg/day.
- Day 8: stop administration of escitalopram.
Start fluoxetine- No wash-out period is needed.
- Day 9: start fluoxetine in normal dosage of 20 mg/day.
More information- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- Fluoxetine slows the metabolism of escitalopram by inhibition of CYP2C19, CYP2D6 and CYP3A4
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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