Changes

| stop = * '''Before day 1:''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day{{StopSSRI, when this dosage is > 10 mg/day. * '''Day 1:''' when a dosage of 10 mg/day is reached, stop administrationSNRI}}| start = * A wash-out period is not necessary, , but care is needed. * '''Day 1:''' start administration of vortioxetine in a dosage of 10 mg/day.{{StartAntidepressant}}| info = * Escitalopram is a weak inhibitor of CYP2D6, which metabolizes vortioxeine. * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Patients could be directly switched from a SSRI or a SNRI to Safe target dose vortioxetine = 10 mg/day. One week after initiation with vortioxetine, the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]</ref>* {{theorSS}}