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Fluoxetine-amitriptyline

630 bytes added, 15:10, 1 May 2009
Created page with '{{ Drugswitch | from = fluoxetine | to = amitriptyline | stop = * Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a...'
{{ Drugswitch
| from = fluoxetine
| to = amitriptyline
| stop =
* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
* When a dosage of 20 mg/day is reached, stop administration.
| start =
Caution is necessary for at least four weeks.
* '''Day 1:''' start administration of amitriptyline in a low dosage of 25 mg/day.
* '''Day 8:''' increase dosage of amitriptyline to 50 mg/day.
* '''Day 15:''' if necessary, increase dosage of amitriptyline to 50-150 mg/day.
| info =
* Fluoxetine slows the metabolism of amitriptyline via CYP2D6.
* Start low, go slow for amitriptyline.}}
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