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* '''Day 1-282:''' start administration of bupropion in a low dosage of 150 mg/day.* '''Day 29 and on30:''' if necessary gradually increase bupropion to 300 mg/day.
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* Fluoxetine and bupropion inhibit both their metabolism through CYP P450-enzymesBupropion inhibits CYP2D6 which metabolizes fluoxetine. {{longt1/2fluvox}}
* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks.
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