* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration.{{stopFluoxetine1}}
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* '''Day 1:''' no administration of fluoxetine and bupropion (“wash-out” period of one day).* '''Day 2:''' start administration of bupropion in a low dosage of 150 mg/2 days (every other day). * '''Day 830:''' continue administration of if necessary gradually increase bupropion is normal dosage of 150 to 300 mg/day. | info =* Bupropion inhibits CYP2D6 which metabolizes fluoxetine.{{longt1/2fluvox}}* Because of the normal half-life of 1 week of desmethylfluoxetine, there should be a low dosing of bupropion during 4 weeks. }}
