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Fluoxetine-moclobemide

73 bytes removed, 15:31, 21 October 2015
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| to = moclobemide
| stop =
* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration.{{stopfluoxetine1}}
| start =
* '''Day 18-2836:''' a wash-out period of four weeks is necessary.* '''Day 2937:''' start moclobemide in a normal dosage of 300 mg/day, if necessary increase dose with 25% (up to 50%) of the target dose every 3 days.
| caveat =
* Occurrence of serotonin syndrome is reported when a wash-out period (of four weeks) is not considered.
| info =
* The pharmacologically active metabolite desmethylfluoxetine has a half-life of about 1 week.
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