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Fluoxetine-paroxetine

235 bytes removed, 12:45, 28 October 2015
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| to = paroxetine
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* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration.{{stopFluoxetine1}}
| start =
No wash-out period is needed.
* '''Day 12:''' start paroxetine the next day in low dosage of 10 mg/day.* '''Day 1415:''' increase dosage of paroxetine to 20 mg/day.
| info =
* Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary. {{longt1/2fluvox}}
* {{theorSS}}
* Fluoxetine and norfluoxetine inhibit de metabolism of paroxetine via CYP2D6.
* Paroxetine inhibits the metabolism of fluoxetine via CYP2D6.
{{review}}
}}
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