[[File{{Drugswitch | from = fluoxetine| to = vortioxetine | stop = * '''Before day 1:Empty''' reduce dosage of fluoxetine to 20 mg/day, when this dosage is > 20 mg/day.jpg]]* '''Day 1:''' stop administration| start = * '''Day 1-21:''' A wash-out period is needed. * '''Day 22:''' Start vortioxetine in a dosage of 10 mg/day.* '''After day 28 :''' If necessary, increase gradually the dosage of vortioxetine.| info = * Fluoxetine slows the metabolism of vortioxetine via CYP2D6, so caution is necessary for at least four weeks after stopping fluoxetine.* {{theorSS}}{{review}}}}