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| to = vortioxetine
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* '''Before day 1:''' gradually reduce dosage of escitalopram fluoxetine to a maximum of 10 20 mg/day, when this dosage is > 10 20 mg/day. * '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration
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* '''Day 1-21:''' A wash-out period is not necessary, but care is needed.* '''Day 122:''' start administration of Start vortioxetine the next day in a dosage of 10 mg/day.* '''After day 28 :''' If necessary, increase gradually the dosage of vortioxetine.| info =* Fluoxetine is a strong inhibitor slows the metabolism of vortioxetine via CYP2D6, which metabolizes vortioxetine. * Occurrence of serotonin syndrome is theoretically possible, so caution is necessaryfor at least four weeks after stopping fluoxetine.* {{theorSS}}{{review}}
}}
