Flupenthixol LA-Olanzapine LA
- Day 1: Last depot injection
- Start depot according to general dosing advice on the day you normally would have injected the former depot.
- Testing for acceptance and possible allergic reactions in a low dose can be carried out earlier.
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.
- It is safer first to switch to oral olanzapine and afterwards to olanzapine pamoate. See Switchtable
- Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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