Changes

| stop = * '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 100 mg/day when the dosage is > 100 mg/day. * '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 50 mg/day.* '''Day 8:''' stop administration of fluvoxamine{{StopSSRI,SNRI}}

Caution is necessary.* '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.* '''Day 8:''' continue administration increase dosage of amitriptyline in to a dosage of 50 mg/day. * Start low, go slow!

* Fluvoxamine fluvoxamine slows the metabolism of amitriptyline via CYP1A2 and CYP2D6CYP2C19 inhibition.* {{theorSSSSCYPinh}}* {{TCAplasmalevelmonitoring}}