Changes

| stop = * '''Day 0:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 25 mg/day. {{StopSSRI,SNRI}}

Caution is necessary.* '''Day 1:''' simultaneously start administration of imipramine in a low dosage of 25 mg25mg/day.* '''Day 8:''' stop administration of fluvoxamine and continue administration increase dosage of imipramine in to a dosage of 50 mg/day. * Start low, go slow!

* Fluvoxamine fluvoxamine slows the metabolism of imipramine via CYP1A2 and CYP2D6CYP2C19 inhibition.* {{theorSSSSCYPinh}}* {{TCAplasmalevelmonitoring}}