Difference between revisions of "Fluvoxamine-moclobemide"

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| to = moclobemide  
 
| to = moclobemide  
 
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* '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
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{{Generaldecrease25p3d}}
* '''Day 1:''' reduce dosage of fluvoxamine further to 25 mg/day.
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* '''Day 8:''' stop administration of fluvoxamine.
 
 
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| start =   
* '''Day 8-13:''' a wash-out period of one week is necessary.
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{{MAOIncrease25p}}
* '''Day 14:''' start moclobemide the next day in a normal dosage of 300 mg/day.
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{{caveSS}}
* A switch from fluvoxamine to moclobemide is not obvious, given the necessary prolonged wash-out period in this case.
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{{SSRI14d}}
* Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.}}
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Latest revision as of 14:40, 16 June 2016

Fluvoxamine
Type Antidepressant
Group SSRI
links
Medscape Fluvoxamine
PubChem 5324346
PubMed Fluvoxamine
Kompas (Dutch) Fluvoxamine
Wikipedia Fluvoxamine
Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide

Switch medication from fluvoxamine to moclobemide.[1] [2]

Nietinrijdenbord.png Stop fluvoxamine
  • Decrease with about 25% of original dose every 3 days
  • Stop and wait 7 days for washout
Eenrichtingbord.png Start moclobemide
  • Start at the first day after the washout period with about 25% of target dose.
Letopbord.png Cave
  • Occurrence of the serotonin syndrome is possible without wash-out period.
  • The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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