Changes

* '''Day 15-3022:''' a wash-out period of at least two weeks one week is necessary. <ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|dosulepine}}</ref> * '''Day 3123:''' start doslulepine dosulepine 25 mg/day.Increase the dose with about 25% of the target dose every 3 days. | info = * Occurrence of the serotonin syndrome is possible without wash-out period.{{HypericumInfo}}* Hypericum induces enzymes of the CYP P-450 type and P-gp.{{caveSS}}* Hypericum probably has MAO-inhibiting properties.}}