Changes

* '''Day 1-14:''' Gradually gradually decrease the dosage of hypericum.

* '''Day 15-3022:''' a wash-out period of at least two weeks one week is necessary. * <ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern'Day 31herbal antidepressant:''' start fluoxetine 20 mg/daypharmacokinetics of active ingredients. Clin Pharmacokinet.| caveat = * Occurrence of the serotonin syndrome is possible without wash2006;45(5):449-out period68.}}</ref><ref>{{LitPubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-SSRIlabel comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-Hypericum8.}} </ref><ref name="informatorium">{{Lit-SSRI-Hypericum2KNMP|fluoxetine}}</ref> * '''Day 23:''' start fluoxetine at 100% of the target dose.* ''' After day 23: ''' gradually increase dose as necessary