Changes

* Administration '''Day 1-14:''' Gradually decrease the dosage of hypericum. * '''Day 15:''' Stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-722:''' a A wash-out period of at least one week is necessary.<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|sertraline}}</ref>* '''Day 823:''' start administration of Start sertraline in a dosage of 25 mg/day.* '''Day 15After day 44:''' If necessary increase dosage of sertraline gradually to 50 -200 mg/day.* If necessary, increase dosage of sertraline further.| info = * Occurrence of the serotonin syndrome is theoretically possible.{{HypericumInfo}}* {{caveSS}}{{Lit-SSRI-Hypericum slows the metabolism of sertraline via CYP3A4. This effect may persist up to two weeks after stopping hypericum, so caution is necessary.}} {{Lit-SSRI-Hypericum2}}}}