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Imipramine-citalopram

529 bytes removed, 12:25, 30 June 2023
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| to = citalopram
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* '''Before day 0:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.{{TCAdecrease25p3d}}| start = * '''Day 1:''' simultaneously start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.* '''Day 8:''' stop administration of imipramine and continue administration of citalopram/escitalopram.{{StartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose citalopram = 20 mg* Citalopram/escitalopram are a weak inhibitor of CYP2D6, which metabolizes imipramine. }}

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