| to = sertraline
| stop =
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.{{TCAdecrease25p3d}}| start = {{StartAntidepressant}}* '''Day 4:''' simultaneously start administration of sertraline in a normal dosage of 50 mg/day.| info =* '''Day 8:''' stop administration of imipramine and continue administration of Safe target dose sertraline in a dosage of = 50-100 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Sertraline is a weak inhibitor of CYP2D6, which metabolizes imipramine.
}}
