Changes

* '''Before day 0:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.* '''Day 3:''' reduce dosage of maprotiline to 25 mg/day.{{downNortriptyline}}| start = * '''Day 3:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.* '''Day 8:''' stop administration of maprotiline and continue administration of paroxetine.{{startmapnorcyp2d6}}

* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes maprotilinenortriptyline. * Safe target dose paroxetine = 20 mg }}