Switch medication from mirtazapine to amitriptyline.
- Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
- Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
- No wash-out period is needed.
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