* Gradually reduce dosage of nortriptylin to a maximum of 50 mg/day. * When a dosage of 50 mg/day is reached, stop administration.{{TCAdecrease25p3d}}
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* No wash-out period is needed.
* Start administration of maprotiline the next day in a normal dosage of 25-75 mg/day.{{TCAincrease25p3d}}
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* Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.* Actually maprotiline is a TCA with a carbon bridge, so it is also called TetraCyclicAntidepressant.{{TCAplasmalevelmonitoring}}
